Scientific Leadership in IEF
WCBP 2009
Application of Quality by Design (QbD) -
Principles to Method Validation
Chantal Felten, PhD
Manager Biologics Analysis
Cardiome Pharma Corp.
Characterization of a Humanized IgG4 Monoclonal Antibody’s Charge Heterogeneity
Protein Analytical Chemistry II
Daniel McDonald, Jennifer Wang, Victor Ling
Genentech Inc., 1 DNA Way, South San Francisco, CA 94080
Chemical Interference in Capillary Isoelectric Focusing (cIEF)
That Distorts the pH Gradients Created by Carrier Ampholytes
Jiaqi Wu, Tiemin Huang
Convergent Bioscience Ltd., Toronto ON M8Z 2L8 Canada
Imaged Capillary Isoelectric Focusing (ICIEF)
From Method Selection, Development, Validation to Transfer
Zara Safarian, PhD
Genentech Inc., 1 DNA Way, South San Francisco, CA 94080
Lot to Lot Variation of Carrier Ampholytes Used in
Isoelectric Focusing (IEF)
Jiaqi Wu
Convergent Bioscience Ltd., Toronto ON M8Z 2L8 Canada
Photostability of a Recombinant Monoclonal Antibody
1 Protein Analytical Chemistry, 2 Early Stage Pharmaceutical Development
Hongbin Liu1, Patricia Molina1, Yilma Adem2 and Osi Esue2
Genentech Inc., 1 DNA Way, South San Francisco, CA 94080
Risk Assessment for Critical Methods Parameters in cIEF Methods
Jiaqi Wu
Convergent Bioscience Ltd., Toronto ON M8Z 2L8 Canada
Risk Assessment for Critical Method
Parameters in cIEF Method
-Changes in Chemicals and Instruments
Jiaqi Wu
Convergent Bioscience Ltd., Toronto ON M8Z 2L8 Canada
The Linearity and Resolving Power of High pH Range Carrier Ampholytes
Tiemin Huang, Fang Huang, Jiaqi Wu
Convergent Bioscience Ltd., Toronto ON M8Z 2L8 Canada