Scientific Leadership in IEF

CEPharm 2006

1. Applications of Imaged Capillary Isolectric Focusing in Biopharmaceutical Drug Development

Mats Holmquist
BioProcess R&D, AstraZeneca, Sődertälje, Sweden

2. Capillary Isoelectric Focusing Method Development for Bone Morphogenetic Protein 7

Yongmei Wang, Jim Stahl
Analytical Development, Stryker Biotech LLC.,
       Hopkinton, MA 01748

3. Characterization of Charge Heterogeneity in Therapeutic Proteins Using Imaging Capillary Isoelectric Focusing

Carrie L. Anderson, Richard R. Rustandi,
        Michael W. Washabaugh, Yang Wang
Merck & Co. Inc., West Point, PA USA

4. Charge Heterogeneity Analysis of a Kunitz Domain Protein and its Associated Product-Related Species: A Comparison of Orthogonal Methods

Kelly Neelon, Jeffrey Muddiman, Jason Wolkovitz,
        Craig Bodycombe, Arthur Ley and Mark Stochl
Dyax Corp., Cambridge, MA USA 02139

5. cIEF in Early Discovery, Product Quality and Stability Assessment

Liqiang Lisa Zhou, Georgeen Gaza-Bulseco, Rong-Rong Zhu
         and Hongcheng Liu
Protein Analytics, Abbott Bioresearch Center,
       Worcester, MA

6. Comparison of Different Methods Used for the Determination of Isoform Distribution in rHuEPO

Louise Chen, Elaine Smith, Nimesh Savjani, David Le,
        Gary Rogers
Amgen Inc., Thousand Oaks, CA USA

7. Determination of charge heterogeneity for mAbs by iCE: Method Development,Validation and Application in a QC Environment

Xiaoping Z. He
Pharmaceutical Sciences - Global Biologics,
Pfizer Global Research and Development,
       St. Louis Laboratories, MO USA

8. Development and Validation of a Generic iCE Method for Control of Charge Heterogeneity in Monoclonal Antibodies and Application in a QC Environment

Xiaoping Z. He
Pharmaceutical Sciences - Global Biologics,
Pfizer Global Research and Development,
       St. Louis Laboratories, MO USA

9. How Useful is the Whole-Column-Imaging Capillary Isoelectric Focusing (cIEF) in the Detection of Different Modifications of Monoclonal Antibodies

Ming-Ching Hsieh, Meinuo Li, Tun Liu, Shanmuuga Sundaram,
        Jun Liu, Li Yang, Yuemei Ma, Alice Matathia, Babita Saxena,
        Richard Crowley, Ann Daus and Qinwei Zhou*
        *Corresponding Author, qinwei.zhou@imclone.com
Department of Bioanalytical Science,
ImClone Systems Incorporated, Branchburg, NJ 08876

10. How Useful is the Whole-Column-Imaging Capillary Isoelectric Focusing (cIEF) in the Detection of Different Modifications of Monoclonal Antibodies (Poster)

Ming-Ching Hsieh, Meinuo Li, Tun Liu, Shanmuuga Sundaram,
        Jun Liu, Li Yang, Yuemei Ma, Alice Matathia, Babita Saxena,
        Richard Crowley, Ann Daus and Qinwei Zhou*
        *Corresponding Author, qinwei.zhou@imclone.com
Department of Bioanalytical Science,
ImClone Systems Incorporated, Branchburg, NJ 08876

11. Introduction of an Imaged cIEF Method into a QC Lab for Mab Analysis

Jifeng Zhang
Amgen, Inc., Thousand Oaks, CA, USA

12. Isoelectric Point Value Comparison between Convergent Bioscience’s pI Markers and Commonly Used Protein pI Markers

Jiaqi Wu, Tiemin Huang
Convergent Bioscience Ltd.,
       Toronto, Ontario, Canada M8Z 2L8

13. Understanding Commercial Carrier Ampholytes Used in cIEF by Using Whole-Column Detection cIEF

Jiaqi Wu
Convergent Bioscience Ltd.,
       Toronto, Ontario, Canada M8Z 2L8

14. Implementation of SDS CGE and cIEF Methods for GMP Testing of Monoclonal Antibodies: Method Development, Validation, and Transfer Experiences

Meg Ruesch, Ph.D.
Pfizer Global Biologics, Analytical Research &        Development,
       St. Louis Laboratories, MO USA

For more presentations, please go to www.ciefforum.com/WCBP06TechDocs/ and
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